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The first season of House M.D. aired from November 16, 2004 to May 24, 2005.
A young kindergarten teacher is brought to the hospital and diagnosed with inoperable brain cancer by Wilson. However, when she doesn't improve with treatment, Wilson seeks out House for another opinion. When House fumbles the initial diagnosis, the patient tires of being a guinea pig just as House feels he has found the right answer. Meanwhile, new hire Eric Foreman tries to get used to working with the world's most difficult diagnostician. Cuddy, frustrated with House's lack of a work ethic, decides to go to extreme measures to get House back into the habit of working in the clinic.
A 16-year-old boy comes to the hospital complaining of double vision and night terrors after being hit in the head by a lacrosse stick. House is dismissive until he notices a myoclonic jerk in the boy's foot. After a near-fatal hallucination and several faulty diagnoses, House is mystified until he learns the boy's true paternity.
After a spirited sexual intercourse with his fiancee, Brandon collapses, suffering from abdominal pain, nausea, fever, and low blood pressure. House and his team cannot pinpoint Brandon's problem since there is no illness with this many symptoms. But then, Brandon complains of pain in his fingers and House suddenly zeroes in on the cause.
When a newborn has a seizure and another newborn becomes ill, House believes an epidemic is spreading through the hospital. Cuddy dismisses the suggestion until other babies show up with the same symptoms. House and his team race against time to diagnose the illness, but the choices they have to make may be lethal to some of the newborns if their diagnosis is incorrect.
When a nun comes in to the clinic with bleeding hands, House gives her an antihistamine which appears to set off an allergic attack. However, when the nun gets tachycardia from the epinephrine House gives her to treat it, Cuddy concludes he gave her ten times the appropriate dose. When House insists he gave her the proper dose, Cuddy gives him 24 hours to prove the nun has another condition before she calls the malpractice lawyers. Although House finally vindicates himself, the answer doesn't help the patient, who continues to get worse no matter what steps they take.
While dodging Cuddy in the emergency room, House runs into the son of a schizophrenic woman who has been diagnosed with alcoholism. Intrigued by her schizophrenia and the fact she has a condition she's too young to get, he takes her case and finds multiple problems. However, when the patient does something unexpected, House starts to wonder if she's really mentally ill at all.
The cause of a woman's hypersomnia turns out to be obvious, but with no way to explain how she could get ill, the only way the patient's husband can save her is by admitting he can't trust her.
House tries to blow off a case of a sick teenager, but when the obvious explanations are ruled out he gets interested. He soon figures out the correct diagnosis, but when the patient takes a turn for the worse, pinning down the exact cause of the patient's illness soon becomes vital. Just when House figures he's got it right, another patient shows up who seems to have no connection to the original patient. When House thinks he's found the right answer, he finds that the patient's mother has lost all faith in him and won't allow treatment.
A famous musician with ALS loses all hope when he realizes he can no longer play his trumpet. However, House doubts the ALS diagnosis is correct and encourages Foreman to pursue an aggressive course of treatment. When House defies the patient's "Do Not Resuscitate" order and is kept away from the patient, he still won't let the matter drop.
Wilson is convinced a homeless Jane Doe in the emergency room has a real illness, but Foreman is convinced she's faking symptoms to stay in the hospital. House takes the case just to spite Foreman, but even when they find who she is and what's wrong with her, the treatment makes her worse.
A teenage boy is admitted when he starts coughing up blood. He gets worse in the hospital, which seems to rule out an environmental cause, or does it? Meanwhile, House tries to prove he isn't addicted to Vicodin by betting a week without Vicodin against a month without clinic duty, but when he suffers withdrawal symptoms, his team starts to lose confidence in his judgment.
A famous baseball player coming off a drug suspension breaks his arm merely by pitching. Tests show that his bones are deteriorating and when a solution is proposed that will mean the death of the patient's unborn child, House must scramble to find another treatment.
A Ouija board tells a young boy he will die, and he soon comes down with a serious illness. As his father is a major donor to the hospital, he insists on the best they have and Cuddy presses House to take the case. As they work through the possible solutions, House wonders why the father is so familiar with certain rare diseases. Meanwhile, a visitor to the hospital allows House to put Chase under the microscope.
A young, high powered CEO of a cosmetic company starts to suffer intense pain. House quickly diagnoses the problem, but realizes revealing the truth about it will mean the patient's certain death. Instead, he risks his own career to hide the truth and get her the treatment she needs. During all this, Princeton-Plainsboro takes on a rich new chairman of the board who has just offered a $100,000,000 donation. He immediately sees House as dead weight and decides to infiltrate House's team to get ammunition against him.
A judge orders House to treat a mob informant. House does so under protest, but even when the patient recovers, he figures something is wrong with him and wants to keep treating him. When he butts heads with Vogler over the treatment of the patient, Vogler spends two days fighting with Cuddy over House's continued employment, resulting in Cuddy having to make a terrible compromise in order to keep House at the hospital. Meanwhile, House figures out someone on his team is keeping Vogler informed and takes steps to try to confirm who it is.
A morbidly obese 10-year-old girl has a heart attack. House is intrigued, but the obvious cause of her problems seems to be her weight, and Chase won't stop mentioning it. Can the team look through her appearance to see the real cause?
When a politician friend of Vogler's collapses at a rally, he demands House at least examine the man. House soon takes an interest in the case, but his conclusions seem to end any chance the patient has of pursuing his political career. In addition, Vogler's demands on House increase to the point where he wants House to shill for his new pharmaceutical.
House quickly diagnoses a pregnant woman, but she resists treatment because of the risk to her unborn baby. When House tries to bend the rules to get her the best treatment available, he finds Vogler standing in his way. Finally, the dispute between them comes down to a showdown before the Board and Wilson gets caught in the crossfire. However, when House once again pulls off the impossible, Cuddy has to decide whether to risk her own career.
House is drawn away from trying to get Cameron to return to PPTH when a meningitis epidemic overwhelms the Princeton area hospitals. When he comes across a 12-year-old diver with symptoms that don't quite fit meningitis, Cuddy figures he's just trying to get out of the boredom of screening dozens of people. However, when the diver gets worse, House finds the hospital's resources stretched to the breaking point.
When House snaps at a patient in the clinic, the patient appears to suffer a stroke as a result of the confrontation. To avoid legal trouble, he agrees to take the patient's case. However, when none of the easy answers are right and the patient soon gets worse, House has to push past the patient's lies to find the right diagnosis.
Cuddy wants House to deliver a lecture to the medical students on diagnostics, and House finally agrees when she lets him off of clinic duty for a couple of hours. On the way to the lecture, he finds his ex-girlfriend coming to see him to ask him to treat her husband. After refusing, he heads to the lecture where one of the cases he presents starts to look very familiar.
House's ex-girlfriend Stacy Warner's husband Mark is reluctant to be treated by House, but they eventually corral him and get him into the hospital. Although Mark insists he is fine and the initial tests bear him out, it is soon clear that there is something seriously wrong with him. House is torn emotionally between wanting to please Stacy by curing Mark and letting Mark die: either so she might come back to him or to hurt her for the way she hurt him. The matter only gets worse when the only way to confirm House's diagnosis is to risk Mark's life.
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